Antibodies to an Intracellular Antigen Penetrate Neuronal Cells and Cause Deleterious Effects
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چکیده
منابع مشابه
Monoclonal antibodies against human ribosomal P proteins penetrate into living cells and cause apoptosis of Jurkat T cells in culture.
OBJECTIVE This study was designed to determine the role of autoantibodies to the ribosomal P protein (anti-P Abs) in the pathogenesis of systemic lupus erythematosus (SLE) using monoclonal anti-P antibodies (anti-P mAbs). METHODS Anti-P mAbs were prepared by a standard hybridoma procedure using recombinant human P1 and P2 proteins as immunogens. We studied the reactivities of these mAbs to P ...
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It is puzzling how autoreactive B cells that escape self-tolerance mechanisms manage to produce Abs that target vital cellular processes without succumbing themselves to the potentially deleterious effects of these proteins. We report that censorship indeed exists at this level: when the Ab synthesis in the cell is up-regulated in IL-6-enriched environments (e.g., adjuvant-primed mouse peritone...
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There are overwhelming data supporting the inflammatory origin of some epilepsies (e.g., Rasmussen's encephalitis and limbic encephalitis). Inflammatory epilepsies with an autoimmune component are characterized by autoantibodies against membrane-bound, intracellular or secreted proteins (e.g., voltage gated potassium channels). Comparably, little is known regarding autoantibodies targeting nucl...
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D iabetic neuropathies are a group of clinical syndromes that affect distinct regions of the nervous system, singly or combined, and markedly affect quality of life (1) and activities of daily living and increase morbidity and mortality (2). Therapy directed at the basic pathogenesis is sorely needed. Neurologic complications occur equally in type 1 and type 2 diabetes and additionally in vario...
متن کاملProduction and Characterization of Murine Monoclonal Antibodies to Leishmania Gp63 Antigen
Background : Production of monoclonal antibodies to Leishmania antigens assists the identification and characterization of these organisms. Objective: Production of monoclonal antibodies against epitopes on the gp63. Methods: Two murine monoclonal antibodies to gp63 were produced and characterized. The reactions of both antibodies with soluble leishmanial antigens, purified gp63 and truncated r...
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ژورنال
عنوان ژورنال: Journal of Clinical & Cellular Immunology
سال: 2013
ISSN: 2155-9899
DOI: 10.4172/2155-9899.1000134